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Preheat Oven: Preheat your oven to 350°F and grease a 9×13-inch baking dish with nonstick spray.
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Cook Beef and Sauce: In a large skillet over medium-high heat, cook the ground beef and onion until the beef is browned and cooked through, about 10 minutes. Add minced garlic and cook for an additional minute.
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Prepare Sauce: Stir in the tomato sauce and Italian seasoning. Let the mixture simmer for 5 minutes, stirring occasionally. Season with salt and pepper to taste. Remove from heat and set aside.
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Cook Noodles: While the sauce simmers, cook the egg noodles according to the package instructions in a large pot of salted boiling water. Drain and set aside.
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Combine Dairy Mixture: In a large mixing bowl, combine the sour cream and cottage cheese. Add the cooked egg noodles, and season with salt and pepper. Stir until evenly combined.
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Layer the Casserole: Spread half of the egg noodle mixture into the prepared baking dish. Top with half of the meat sauce. Repeat the layers with the remaining egg noodles and meat sauce.
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Add Cheese and Bake: Sprinkle the grated cheddar cheese evenly over the top. Bake in the preheated oven until the sauce is bubbly and the cheese has melted, about 30 minutes.
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Cool and Serve: Let the casserole cool for 10 minutes before serving. Enjoy!