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Cook the Pasta:
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Bring a large pot of salted water to a boil. Add the pasta and cook until al dente according to the package instructions. Drain and set aside.
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Prepare the Cheese Sauce:
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In a large saucepan, melt the butter over medium heat. Add the flour and whisk continuously for about 2 minutes to form a roux.
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Gradually whisk in the milk, ensuring no lumps form. Continue to cook, stirring constantly, until the mixture thickens and starts to bubble.
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Reduce the heat to low and stir in the shredded cheddar, Gruyère, mozzarella, and Parmesan cheeses. Stir until the cheese is completely melted and the sauce is smooth.
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Add the Dijon mustard, garlic powder, onion powder, salt, pepper, and cayenne pepper (if using). Mix well.
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Combine the Pasta and Cheese Sauce:
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Add the cooked pasta to the cheese sauce and stir to coat the pasta evenly.
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Add the Seafood:
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Gently fold in the chopped lobster, shrimp, and crab meat until well combined.
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Prepare the Topping:
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In a small bowl, mix the panko breadcrumbs with the melted butter and grated Parmesan cheese.
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Assemble and Bake:
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Preheat your oven to 375°F (190°C).
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Transfer the macaroni and cheese mixture to a greased 9×13-inch baking dish or a similar-sized casserole dish.
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Sprinkle the breadcrumb mixture evenly over the top of the macaroni and cheese.
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Bake in the preheated oven for 25-30 minutes, or until the top is golden brown and the sauce is bubbly.
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Serve:
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Remove from the oven and let cool slightly.
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Garnish with chopped fresh parsley, if desired.
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Serve hot and enjoy your luxurious Lobster, Crab, and Shrimp Macaroni and Cheese!